This in turn can be overcome by conjugation to PEG which results in an increased half-life to proteins to which it is attached, either by avoiding renal clearance since polymer increases the apparent size of the molecule to above the glomerular filtration limit, and/or through evasion of cellular clearance mechanisms (Chapman 2002; National Horizon Scanning Centre 2004)

This in turn can be overcome by conjugation to PEG which results in an increased half-life to proteins to which it is attached, either by…