(Table-II)

(Table-II). Table-II Laboratory examination results of patients of with moderate disease activity and of with moderate-severe disease activity. 0.05) In contrast, ultrasonic examination SU5614 results showed that this synovial thickness of joints of patients of severe activity was significantly larger than that of the group with mild activity with a statistically significant difference ( 0.05), SU5614 indicating that the synovial thickness of joints is indie of anti-CCP antibodies, but is positively related to disease activity. The changes of joint ultrasonography were also compared between positive and negative anti-CCP antibodies group. Results: It is found that the number of patients suffering from joint involvement in the unfavorable anti-CCP antibody group was larger than that of the anti-CCP positive antibody group ( 0.05); the thickness of the synovium of joints of patients in the group with moderate-severe disease activity evaluated via ultrasonography was significantly larger than that of the group with moderate disease activity ( 0.05). Conclusion: It is possible to observe the degree of disease activity dynamically by combining ultrasonography with SU5614 anti-CCP antibody and make a better assessment of patients to facilitate treatment. 0.05 meant that this difference was of statistical significance. RESULTS The anti-CCP antibodies and RF of the group with positive anti-CCP antibodies were significantly higher than that of the group with unfavorable anti-CCP antibodies, and the difference was of statistically significant ( 0.05). The comparison of the synovial thickness of joints, ESR, and DAS28 score between the two groups showed that this difference was not statistically significant ( 0.05). Based on the test results of anti-CCP antibodies, the number of patients in the group with positive anti-CCP antibodies was 42, and that in the group with unfavorable anti-CCP antibodies was 40. Ultrasonic examination results showed that this numbers of affected joints of the two groups were: wrist joint: 38 vs. 35, metacarpophalangeal joints: 64 vs. 120, proximal interphalangeal joint: 43 vs. 45, elbow joint: 1 vs. 1, knee joint: 11 vs. 0, and ankle joint: 3 vs. 0. The total numbers of affected joints of the two groups were 160 and 201, respectively. Ultrasonic examination results of the group with positive anti-CCP antibodies showed that among the patients with joints affected, 8 patients suffered from arthroedema, one patient from bone erosion, and 27 patients from synovial pannus formation. Ultrasonic examination results of the group with unfavorable anti-CCP antibodies showed that among the patients with joints affected, two patients suffered from arthroedema, no one from bone erosion, and no patients from synovial pannus formation. (Table-I) Table-I Laboratory examination results patients with RA with positive anti-CCP antibodies and with unfavorable anti-CCP antibodies. 0.05]. Ultrasonic examination results showed that this synovial thickness of the joints of the group with moderate-severe disease activity was significantly larger than that of the group with moderate disease activity, and the difference was statistically significant [(2.7 1.2) mm, (2.1 0.7) mm, 0.05]. (Table-II). Table-II Laboratory examination results of patients of with moderate disease activity and of with moderate-severe disease activity. 0.05) In contrast, ultrasonic examination results showed that this synovial thickness of joints of patients of severe activity was significantly larger than that of the group with mild activity with a statistically significant difference ( 0.05), indicating that the synovial thickness of joints is indie of anti-CCP antibodies, but is positively related to disease activity. This obtaining is usually of great guiding significance for RA treatment. Clinically, patients medication should be based on clinical symptoms, ESR, CRP, and Doppler ultrasonic examination results (especially power Doppler ultrasonography) to ensure scientific and demanding treatment. Recent studies have also shown that certain types of ultrasound and MRI have almost the same accuracy in the diagnosis and evaluation of RA. It is necessary to use ultrasound and anti CCP antibody to evaluate RA in the future. 6 By affected joint count detected via ultrasonography in this study, the affected joint count (201) (including wrist joint, metacarpophalangeal joints, and proximal interphalangeal joint) of the group with unfavorable anti-CCP antibodies is usually significantly larger than that of the group with positive anti-CCP antibodies (160). Although anti-CCP antibodies are of high PLCG2 specificity and sensitivity and are vital to diagnosing RA, some patients will turn out to be unfavorable in anti-CCP antibodies. In such a case, color Doppler ultrasonography can be used to observe the condition of the synovium of the joint, affected joint count, and bone erosion of patients, depending on which of the affected joint counts and locations can be displayed accurately.7 RA is a common disease among middle-aged groups, and especially among women. It is a chronic inflammatory synovial disease including multiple joints and organs. The early pathological switch of RA is usually chronic synovitis, namely synovial membrane oozes and incrassates. Generally, the synovial membrane thickness is not larger than 2 mm. The synovial membrane thickness.