Since Meg3 can interact with p53 directly (25,26,28), it is possible that the interaction between Meg3 and p53 could competitively prevent the binding of p53 to the promoters of these p53-regulated genes, although this mechanism itself cannot explain the selective induction of p53-regulated genes upon Meg3 or PTBP3 silencing

Since Meg3 can interact with p53 directly (25,26,28), it is possible that the interaction between Meg3 and p53 could competitively prevent the binding of p53…