Through the pharmacological targeting of thede novoand sphingomyelin pathways, we demonstrate now, for the very first time, that spinally formed S1P after activation of sphingosine kinase may be the key second messenger adding to morphine-induced hyperalgesia and antinociceptive tolerance at least partly through modulation of glial cell function

Through the pharmacological targeting of thede novoand sphingomyelin pathways, we demonstrate now, for the very first time, that spinally formed S1P after activation of sphingosine…