Although beyond the range of the article, generally there also exist essential types of the contribution of global knockout mice to your understanding of various other less common diseases, like the breakthrough that granulocyte macrophage colony-stimulating aspect (GMCSF)-deficient mice develop pulmonary alveolar proteinosis (PAP) due to ineffective macrophage degradation of ingested surfactant (141)

Although beyond the range of the article, generally there also exist essential types of the contribution of global knockout mice to your understanding of various…